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Novel hasubanan-based analgesics
There are three main medication alternatives for use in treating opioid addiction; methadone, buprenorphine, and naltrexone which can be used separately or in combination (e.g., buprenorphine and naltrexone). All three medications are FDA approved and can reduce opioid cravings helping to sever the ties between opioid use and situational/emotional triggers....
Published: 2/5/2024
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Inventor(s): Thomas Keck, Gustavo Moura-Letts
Keywords(s): Addiction, Neurological disorders, Therapeutic
Category(s): Human Health Care > Therapeutics
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Neuron Foundry
More than a billion people worldwide suffer from some form of a neurological disorder such as Alzheimer's (AD), Parkinson's (PD), multiple sclerosis, epilepsy, stroke, or autism. These conditions result in more than 7 million deaths, with associated costs exceeding $1.5 trillion per year. PD is a neurodegenerative disease that causes severe...
Published: 2/12/2024
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Inventor(s): Charles McGlynn
Keywords(s): Light Energy, Microwave, Neurological disorders, Therapeutic
Category(s): Engineering, Human Health Care > Therapeutics
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Vaccine for the Treatment of Cocaine Addiction and Relapse
Cocaine is the second most trafficked illegal substance in the world with more than 756 metric tons seized every year from authorities. In the United States, over 35 million people over the age of 12 have reported using cocaine, while being the most frequent illegal drugs reported by emergency rooms. Its popularity is due to its highly addictive nature...
Published: 2/9/2024
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Inventor(s): Thomas Keck, Christopher Lowry
Keywords(s): Addiction, Cocaine, Inflammation, PTSD, Vaccine
Category(s): Human Health Care > Therapeutics
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Nanoparticle-based antibody delivery system to selectively inhibit inflammatory mediators and combat “cytokine storm”.
Recent outbreaks with novel coronaviruses including SARS and MERS as well as the ongoing COVID-19 pandemic underscore existing limitations in managing these deadly pathogens. According to the World Health Organization, there have been over 4.3 million confirmed cases of COVID- 19 and ~300,000 deaths to date. SARS, MERS, and COVID-19 infect the airway...
Published: 3/5/2024
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Inventor(s): Dobbins Tabbetha, Sreekant Murthy
Keywords(s): Covid-19, Cytokine-storm, Immunology, Inflammation, Respiratory, Therapeutic
Category(s): Human Health Care > Therapeutics
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Development of genetically engineered probes for calcium sensing and manipulation
Calcium levels in cells have critical functions. Moreover, calcium signaling plays a crucial role in the control of neuronal function and plasticity. Consequently, calcium sensing dysfunction can lead to a variety of pathological conditions such as Alzheimer’s disease or neuromuscular disorders such as Dystonia.
Changes in neuronal Ca2+ concentration...
Published: 3/4/2024
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Inventor(s): Venkat Venkataraman, Anuradha Krishnan, Jeffrey Viviano, Jingyi Zhang
Keywords(s): Alzheimer's, Calcium, Genetics, Neurology, Neuromuscular
Category(s): Human Health Care > Therapeutics
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Neuronal calcium sensor proteins as potential therapeutic targets in circadian rhythm and sleep disorders
Sleep health and sleep disorders are major problems. In the US, an estimated 1/3rd of adults and 2/3rds of highschool aged young adults do not get the recommended amount of sleep. Lack of sleep and poor sleep hygiene is associated with a number of health problems. These include obesity, depression, and cardiovascular disease. Additionally, specific...
Published: 3/5/2024
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Inventor(s): Venkat Venkataraman
Keywords(s): Circadium, Genetics, Sleep, Therapeutic
Category(s): Human Health Care > Therapeutics
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Compositions and Methods to Treat Inflammatory Joint Disease
TechnologyInflammatory joint disease is an autoimmune condition that afflicts more than 54 million adults in the United States. It’s commonly characterized by joints that exhibit pain, stiffness, and redness that ultimately leads to severe disability and premature death. Incidence of the disease is rapidly growing due to rising obesity rates,...
Published: 3/6/2024
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Inventor(s): Paula Carpintero Fernandez, Maria Mayan Santos, Francisco Blanco Garcia, Gary Goldberg
Keywords(s): Autoimmune/Immunology, Disease, Inflammatory, Joint, Obesity, Protein
Category(s): Human Health Care > Therapeutics, Human Health Care > Biomarkers, Diagnosis and Detection
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Novel dopamine D2 receptor ligands for Parkinson’s disease & schizophrenia
Dopamine is a catecholamine neurotransmitter that mediates physiological functions in the central and peripheral nervous systems. Binding of dopamine to the dopamine D2 receptor elicits intracellular signaling implicated in various neurological disorders such as Parkinson’s disease (PD) and schizophrenia. Drugs targeting the dopamine D2 receptor...
Published: 3/4/2024
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Inventor(s): Thomas Keck, Chun Wu
Keywords(s): Compounds, Dopamine D2, Neurological, Parkinson Disease, Schizophrenia, Therapeutic, Treatment
Category(s): Human Health Care > Therapeutics
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Cyclin C and its role in cancer and cancer therapeutics
Cancer is a leading cause of death worldwide with more than 14 million new patients diagnosed and almost 9 million deaths every year. Despite increasing survival rates over the past few decades, current treatments such as radiation, chemotherapy, targeted therapies and new immunotherapies still fail in large subsets of patients. Mounting drug resistance...
Published: 3/13/2024
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Inventor(s): Randy Strich, Katrina Cooper
Keywords(s): Apoptosis, Cancer, Chemotherapy, Cyclin C, Radiation, Synergy, Therapeutic
Category(s): Human Health Care > Therapeutics
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A novel sealant device that aids in stem cell localization
in the treatment of lower back pain
TechnologyOne of the major causes of lower back pain is intervertebral disc (IVD) degeneration also known as lumbar degenerative disc disease which often leads to disk herniation. IVD results from the dehydration of the central nucleus pulposus (NP) which ultimately alters the biomechanics of the disc and eventually causes tears to form in the peripheral...
Published: 2/7/2024
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Inventor(s): Andrea Vernengo, Thomas Christiani, Cristina Iftode, Jennifer Kadlowec
Keywords(s): Back Pain, Biomaterials, Hydrogels, Implant, Polymers, Stem Cells, Tissue Engineering
Category(s): Human Health Care > Biomaterials, Human Health Care > Medical Devices, Human Health Care > Therapeutics
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