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Novel hasubanan-based analgesics
There are three main medication alternatives for use in treating opioid addiction; methadone, buprenorphine, and naltrexone which can be used separately or in combination (e.g., buprenorphine and naltrexone). All three medications are FDA approved and can reduce opioid cravings helping to sever the ties between opioid use and situational/emotional triggers....
Published: 2/5/2024
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Inventor(s): Thomas Keck, Gustavo Moura-Letts
Keywords(s): Addiction, Neurological disorders, Therapeutic
Category(s): Human Health Care > Therapeutics
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Neuron Foundry
More than a billion people worldwide suffer from some form of a neurological disorder such as Alzheimer's (AD), Parkinson's (PD), multiple sclerosis, epilepsy, stroke, or autism. These conditions result in more than 7 million deaths, with associated costs exceeding $1.5 trillion per year. PD is a neurodegenerative disease that causes severe...
Published: 2/12/2024
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Inventor(s): Charles McGlynn
Keywords(s): Light Energy, Microwave, Neurological disorders, Therapeutic
Category(s): Engineering, Human Health Care > Therapeutics
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Nanoparticle-based antibody delivery system to selectively inhibit inflammatory mediators and combat “cytokine storm”.
Recent outbreaks with novel coronaviruses including SARS and MERS as well as the ongoing COVID-19 pandemic underscore existing limitations in managing these deadly pathogens. According to the World Health Organization, there have been over 4.3 million confirmed cases of COVID- 19 and ~300,000 deaths to date. SARS, MERS, and COVID-19 infect the airway...
Published: 3/5/2024
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Inventor(s): Dobbins Tabbetha, Sreekant Murthy
Keywords(s): Covid-19, Cytokine-storm, Immunology, Inflammation, Respiratory, Therapeutic
Category(s): Human Health Care > Therapeutics
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Neuronal calcium sensor proteins as potential therapeutic targets in circadian rhythm and sleep disorders
Sleep health and sleep disorders are major problems. In the US, an estimated 1/3rd of adults and 2/3rds of highschool aged young adults do not get the recommended amount of sleep. Lack of sleep and poor sleep hygiene is associated with a number of health problems. These include obesity, depression, and cardiovascular disease. Additionally, specific...
Published: 3/5/2024
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Inventor(s): Venkat Venkataraman
Keywords(s): Circadium, Genetics, Sleep, Therapeutic
Category(s): Human Health Care > Therapeutics
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Novel dopamine D2 receptor ligands for Parkinson’s disease & schizophrenia
Dopamine is a catecholamine neurotransmitter that mediates physiological functions in the central and peripheral nervous systems. Binding of dopamine to the dopamine D2 receptor elicits intracellular signaling implicated in various neurological disorders such as Parkinson’s disease (PD) and schizophrenia. Drugs targeting the dopamine D2 receptor...
Published: 3/4/2024
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Inventor(s): Thomas Keck, Chun Wu
Keywords(s): Compounds, Dopamine D2, Neurological, Parkinson Disease, Schizophrenia, Therapeutic, Treatment
Category(s): Human Health Care > Therapeutics
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Cyclin C and its role in cancer and cancer therapeutics
Cancer is a leading cause of death worldwide with more than 14 million new patients diagnosed and almost 9 million deaths every year. Despite increasing survival rates over the past few decades, current treatments such as radiation, chemotherapy, targeted therapies and new immunotherapies still fail in large subsets of patients. Mounting drug resistance...
Published: 3/13/2024
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Inventor(s): Randy Strich, Katrina Cooper
Keywords(s): Apoptosis, Cancer, Chemotherapy, Cyclin C, Radiation, Synergy, Therapeutic
Category(s): Human Health Care > Therapeutics
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Targeting Podoplanin to Combat Cancer
Sentrimed® is launching its first product, MASL®, to treat and prevent cancer and arthritis. Our technology is protected by issued patents and proprietary technology tailored to combat cancer and inflammatory diseases by targeting a unique receptor, called podoplanin (PDPN), which is expressed by cancer and inflammatory cells. We have received...
Published: 2/16/2024
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Inventor(s): Gary Goldberg, Yongquan Shen
Keywords(s): Cancer, Compounds, Therapeutic
Category(s): Human Health Care > Therapeutics
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