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Development of genetically engineered probes for calcium sensing and manipulation
Calcium levels in cells have critical functions. Moreover, calcium signaling plays a crucial role in the control of neuronal function and plasticity. Consequently, calcium sensing dysfunction can lead to a variety of pathological conditions such as Alzheimer’s disease or neuromuscular disorders such as Dystonia.
Changes in neuronal Ca2+ concentration...
Published: 3/4/2024
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Inventor(s): Venkat Venkataraman, Anuradha Krishnan, Jeffrey Viviano, Jingyi Zhang
Keywords(s): Alzheimer's, Calcium, Genetics, Neurology, Neuromuscular
Category(s): Human Health Care > Therapeutics
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Neuronal calcium sensor proteins as potential therapeutic targets in circadian rhythm and sleep disorders
Sleep health and sleep disorders are major problems. In the US, an estimated 1/3rd of adults and 2/3rds of highschool aged young adults do not get the recommended amount of sleep. Lack of sleep and poor sleep hygiene is associated with a number of health problems. These include obesity, depression, and cardiovascular disease. Additionally, specific...
Published: 3/5/2024
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Inventor(s): Venkat Venkataraman
Keywords(s): Circadium, Genetics, Sleep, Therapeutic
Category(s): Human Health Care > Therapeutics
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A new serum-based diagnostic for the detection of substance abuse and other
addictive disorders
The proposed technology is a novel approach to a serum biomarker for substance abuse disorder based on the positive correlation between plasma S100B protein levels and addiction. It is proposed that the expression levels of the S100B protein will serve as an indicator of the process of addiction and decision-making. The changes may be detectable in...
Published: 2/13/2024
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Inventor(s): Venkat Venkataraman, Richard Jermyn, Robert Steer
Keywords(s): Addiction, Biomarkers, Diagnostics, Substance Abuse
Category(s): Human Health Care > Biomarkers, Diagnosis and Detection
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